Do not use Epogen from a multi-dose vial if you are pregnant or breast-feeding. Postmarketing Experience The following adverse reactions have been identified during post-approval use of Epogen. Per protocol, the last available hemoglobin values from patients who dropped out were included in the efficacy analyses. Call your healthcare provider if you have unusual tiredness, lack of energy, dizziness, or fainting. Advise a lactating woman not to breastfeed for at least 2 weeks after the last dose. Do Not Freeze or Shake. Epogen has not been proven to improve quality of life, fatigue, or well-being.
This dose will be measured in Units per mL or cc 1 mL is the same as 1 cc. Tell your healthcare provider about any side effects that bother you or do not go away. Do not reuse syringes and needles. This route is usually for hemodialysis patients. Do not give Epogen to other people even if they have the same symptoms that you have. Erythropoietin is also used to treat anemia in people with chronic kidney disease who are not on dialysis those in Stage 3 or 4 disease and those living with a kidney transplant. There may be special state and local laws for disposing of used needles and syringes.
The mechanism of action of Epogen is the same for these two populations. Avoid driving or hazardous activity until you know how this medicine will affect you. Tell your doctor if you are pregnant or plan to become pregnant. Randomization was stratified by type of malignancy lung vs. These may be signs that your body has stopped responding to Epogen. Ask your doctor or pharmacist how to dispose of the puncture-resistant container. When therapy with Epogen is needed in neonates and infants, use the single-dose vial, which is a benzyl alcohol-free formulation.
If you are being treated with dialysis treatment to remove waste from the blood when the kidneys are not working , your doctor may tell you to inject the medication into your venous access port. Risks of therapy include death, , , , and tumor recurrence. Study 4 was a randomized, open-label, controlled, factorial design study in which darbepoetin alfa was administered to prevent anemia in 733 women receiving neo-adjuvant breast cancer treatment. More serious side effects, including allergic reactions, seizures and thrombotic events e. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. A total of 144 48% patients were randomly assigned to receive Epogen and 153 52% patients were randomly assigned to receive placebo. Precursors of red cells, the proerythroblasts and basophilic erythroblasts also express erythropoietin receptor and are therefore affected by it.
You and the person who will be giving the injections should read the manufacturer's information for the patient that comes with epoetin alfa injection before you use it for the first time at home. Throw away the puncture-proof disposable container as instructed by your healthcare provider. Epoetin alfa may also speed up tumor growth, or shorten remission or survival time in some people. Throw the vial away after use even if there is medicine left in the vial. When epoetin alfa injection is used to decrease the risk that blood transfusions will be required due to surgery, it is sometimes injected once daily for 10 days before surgery, on the day of surgery and for 4 days after surgery. Immediately and permanently discontinue Epogen and administer appropriate therapy if a serious allergic or anaphylactic reaction occurs.
Epogen that comes in single-dose vials does not contain benzyl alcohol. Selecting and preparing the injection site: Epogen can be injected into your body using two different ways routes as described below. This can happen even if you have never had high blood pressure before. Pooled Analysis Three T imes P er W eek D osing The results of 6 studies of similar design and that randomized 131 patients to epoetin alfa or placebo were pooled to assess the safety and effectiveness of epoetin alfa. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. No overall differences in safety or effectiveness were observed between geriatric and younger patients.
. The Cochrane Database of Systematic Reviews. Regulatory, Integrative and Comparative Physiology. Epogen that comes in single-dose vials does not contain benzyl alcohol. Store it in the refrigerator, but do not freeze it. Epoetin alfa injection is also used before and after certain types of surgery to decrease the chance that blood transfusions transfer of one person's blood to another person's body will be needed because of blood loss during surgery. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes.
Keep all appointments with your doctor. Eva Bonsdorff and Eeva Jalavisto called the hemopoietic substance 'erythropoietin'. Epogen is used to treat anemia caused by or , or anemia caused by taking to treat human immunodeficiency virus. Do not stop using epoetin alfa injection without talking to your doctor. Because many drugs are present in human milk, caution should be exercised when Epogen from single-dose vials is administered to a lactating woman. Early treatment before an infant is 8 days old with erythropoietin correlated with an increase in the risk of in premature and anemic infants, raising concern that the angiogenic actions of erythropoietin may exacerbate retinopathy. Keep it out of the reach of children and pets.